Objectives: This study examined the structural relationship between family resilience, active coping, adaptive cognitive-emotional control strategy, and post-traumatic growth, to identify factors that help post-traumatic growth in college students who have experienced trauma. Methods: An online questionnaire survey was conducted for four-year college students nationwide, and 561 responses were analyzed using SPSS 25.0 and AMOS 25.0. Results: First, all direct effects between variables were found to be statistically significant. Second, as for the indirect effect between variables, it was found that active coping and adaptive cognitive-emotional regulation strategies mediate the relationship between family resilience and post-traumatic growth of trauma-experienced college students. Third, active coping and adaptive cognitive-emotional regulation strategy were shown to have a sequential intermediate effect on the relationship between family resilience and post-traumatic growth in college students who had experienced trauma. Conclusions: For post-traumatic growth of college students who have experienced trauma, it can be seen that the improvement of family resilience, active coping, and adaptive cognitive-emotional regulation strategy, as well as their sequential improvement, is useful.