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Lipopolysaccharide를 처리한 RAW 264.7 세포에서 백두옹 메탄올 추출물의 항염증 효과
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  • Lipopolysaccharide를 처리한 RAW 264.7 세포에서 백두옹 메탄올 추출물의 항염증 효과
  • The Anti-Inflammatory Effect of Pulsatilla koreana Methanol Extract in Lipopolysaccharid-Exposed RAW 264.7 Cells
저자명
이귀선(Gui Sun Lee),김두희(Doo Hee Kim),박중현(Joong Hyun Park),최희승(Hee Seung Choi),허성규(Seong Kyu Heo),차윤엽(Yun Yeop Cha)
간행물명
대한한방비만학회지KCI
권/호정보
2017년|17권 1호|pp.1-9 (9 pages)
발행정보
한방비만학회|한국
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정기간행물|KOR|
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영문초록

Objectives: This study was performed to identify the anti-inflammatory effect of Pulsatilla koreana (PK) methanol extract on lipopolysaccharide (LPS) induced inflammatory.\nMethods: There were five groups. They were control group, LPS-exposed PK methanol extract group (0 μg/ml, 10 μg/ml, 30 μg/ml, 100 μg/ml). To measure out cytotoxicity of PK, we performed the MTT assay. To evaluate the anti-inflammatory effect of PK, we examined the inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokines (interleukin [IL]-1β, IL-6, tumor necrosis factor-α [TNF-α], IL-10).\nResults: 1. The extract of PK (∼100 μg/ml) itself did not have any cytotoxic effect in RAW 264.7 cells. 2. The concentration of plasma NO and PGE2 in PK methanol extract group showed a lower values than those of control group. 3. The concentration of plasma IL-1β, plasma IL-6, and plasma TNF-α in PK methanol extract group showed a lower values than those of control group. 4. The concentration of Plasma IL-10 in PK methanol extract groups showed higher than control group; however, these values showed no significantly different.\nConclusions: According to this study, the extract of PK could be used as a protective agent against inflammation.

목차

서 론\n재료 및 방법\n결 과\n고 찰\n결 론\n감사의 글\nReferences

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