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The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
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  • The potential molecular effects of bursal septpeptide II on immune induction and antitumor activity
저자명
Guang Fang Zhou, Qing Tao Liu, Bin Zhou, Ya Feng Qiu, Xiao Dong Liu, Zhi Yong Ma, Xiu Li Feng, Rui Bing Cao, Pu Yan Chen
간행물명
Journal of Veterinary ScienceKCI,SCIE,SCOPUS
권/호정보
2015년|16권 3호(통권59호)|pp.325-331 (7 pages)
발행정보
대한수의학회|한국
파일정보
정기간행물|ENG|
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영문초록

The bursa of Fabricius (BF) is the acknowledged central humoral immune organ in birds. Bursal septpeptide II (BSP-II) is an immunomodulatory bioactive peptide isolated from BF. To understand the effects of BSP-II on immune induction, gene expression profiles of hybridoma cells treated with BSP-II were evaluated. Pathway analysis showed that regulated genes were involved in cytokine-cytokine receptor interactions, T cell receptor signaling pathway, and pathway in cancer. It was observed that BSP-II reduced tumor cells proliferation and stimulated p53 expression. These results indicate potential mechanisms underlying the effects of the humoral immune system on immune induction, including antitumor activities. Our study has provided a novel insight into immunotherapeutic strategies for treating human tumors.

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