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Cyclosporine A에 의해 과증식된 조직의 치은섬유아세포에서 MMP-1, TIMP-1, TGF-β1, FGF-2, 그리고 FGF-7의 mRNA 발현에 관한 연구
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  • Cyclosporine A에 의해 과증식된 조직의 치은섬유아세포에서 MMP-1, TIMP-1, TGF-β1, FGF-2, 그리고 FGF-7의 mRNA 발현에 관한 연구
  • The mRNA expression of MMP-1, TIMP-1, TGF- β1, FGF-2 and FGF-7 in gingival fibroblasts induced by cyclosporine A
저자명
마평수,이재선,박창주,황경균,심광섭
간행물명
Journal of Dental Implant Research
권/호정보
2008년|27권 1호(통권29호)|pp.1-13 (13 pages)
발행정보
대한치과이식임플란트학회|한국
파일정보
정기간행물|KOR|
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서지반출

국문초록

Cyclosporine A(CsA)는 광범위하게 사용되는 면역 억제제로, 장기이식환자의 거부반응을 막기 위해 사 용되고, 자가 면역질환의 치료에도 사용되고 있다1-3). CsA 투여와 관련된 부작용은 신독성, 간독성, 고혈압, 신경독성, 치은증식이 보고 되었다.

영문초록

Purpose : Cyclosporine A (CsA) is a widely used immunosuppresive agent with development of gingival overgrowth as a side effect. The mechanisms underlying this immunosuppressive activity are not fully understood. The progression of gingival overgrowth results from the accumulation of extracellular matrix. The purpose of this study was to investigate the mRNA expression of several growth factors associated with CsA according to the induction time and dose. Materials & Methods : Gingival fibroblasts were obtained from gingival tissues of healthy donor and the patients treated with CsA. The cultured gingival fibroblasts were incubated with increasing concentration(0, 250, 500, 750, 1000, 1500, 2000 ng/ml) of CsA for 24, 48, and 72 hours, and the expression of MMP-1, TIMP-1, TGF-β1, FGF-2 and FGF-7 was determined by reverse transcriptase-polymerase chain reaction (RT-PCR). Results : The expression of MMP-1 was slightly decreased according to the concentration of treated CsA in 24 and 48 hours stimulation. There was no change in TIMP-1 expression. TGF-β1 showed the increased expression in 72 hours stimulation and FGF-2 expression was increased in 48 and 72 hours stimulation. The FGF-7 expression was significantly decreased in 48 and 72 hours stimulation. Conclusions : We concluded that the gingival overgrowth might be related with TGF-β1, MMP-1 and FGF-2 expression associated with collagen metabolism. And the FGF-7 associated with keratinocyte growth was significantly related with CsA gingival overgrowth. We also speculated that there was no cellular change associated with CsA induction in gingival fibroblast.

목차

Ⅰ. 서론
II. 연구재료 및 방법
Ⅲ. 연구결과
Ⅳ. 총괄 및 고찰
Ⅴ. 결론
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