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구속 스트레스 쥐 모델에서 스트레스 반응 감소에 대한 사카린 섭취의 효과
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  • 구속 스트레스 쥐 모델에서 스트레스 반응 감소에 대한 사카린 섭취의 효과
  • Effect of Saccharin Intake in Restraint-induced Stress Response Reduction in Rats
저자명
박종민,송민경,김윤주,김연정
간행물명
기초간호자연과학회지KCI
권/호정보
2016년|18권 1호(통권44호)|pp.36-42 (7 pages)
발행정보
한국기초간호학회|한국
파일정보
정기간행물|KOR|
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Purpose: Stress activates the sympathetic nervous system and hypothalamic–pituitary–adrenal (HPA) axis and induces the release of glucocorticoids. Saccharin is 300 times sweeter than sucrose, but does not increase blood insulin levels. Thus, this study was designed to evaluate the effect of saccharin intake in restraint-induced stress response reduction in rats. Methods: Adult male Sprague-Dawley (SD) rats had stress induced by restraint for 2 hours/day for 1 week. Saccharin was provided in sufficient amounts to allow them to intake it voluntarily at 0.1% diluted in water. The Y-maze test and forced swim test (FST) were performed to evaluate cognitive function and the depressive behavior of the rats. The protein expression of the glucocorticoid receptor (GR) in hippocampal cornu ammonis (CA) 1 was investigated by using immunohistochemistry. Results: It was found that, the percentage of alternation in the Y-maze test was significantly (p<.01) higher in the Stress + saccharin group than in the Stress group. Immobility time in the FST was significantly (p<.01) lower in the Stress + saccharin group than in the Stress group. Also, the positive cells of GR in hippocampus CA1 were significantly (p<.05) lower in the Stress + saccharin group than in the Stress group. Conclusion: This study showed that there was an effect of saccharin intake in restraint-induced stress response reduction in rats.

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